Flavonol Glycosides from Euphorbia microsciadia Bioss. with their Immunomodulatory Activities

نویسندگان

  • Abdul Majid Ayatollahi School of Pharmacy and Phytochemistry Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Jean Jules Kezetas Bankeu Department of Organic Chemistry, Faculty of Science, TWAS Research Unit of University of Yaounde I; Yaounde, Cameroon
  • Omer Mohamed Abdalla Dr. Panjwani Center for Molecular Medicine and Drug Research, Sciences, University of Karachi, Karachi-75270, Pakistan.
  • Sayyed Mustafa Ghannadian Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.sfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Suleiman Afsharypour Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Sumaira Hareem Dr. Panjwani Center for Molecular Medicine and Drug Research, Sciences, University of Karachi, Karachi-75270, Pakistan.
چکیده مقاله:

Four known flavonoids: quercetin 3-O-β-D-rutinoside (Q3Rut), myricetin 3-O-β-D-galactopyranoside (M3Gal), quercetin 3-O-β-D-galactopyranoside (Q3Gal) and quercetin 3-O-β-D-glucopyranoside (Q3Glc), for the first time were isolated from aerial parts of Euphorbia microsciadia. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques. The immunomodulatory activities of isolated compounds were compared using standard T-cell proliferation assay. These data showed that lymphocyte suppression activity of flavonoids (1-4) were comparatively lower than prednisolon as a standard drug. Immunosuppressive activity of flavonoids with hydroxyl groups at both 3′-and 4′-positions in their B-ring (Q3Gal) were more than those with 3′-,4′-and 5′-hydroxyl substitution (M3Gal). In these compounds, Q3Gal showed the most inhibitory activity, whereas M3Gal showed the least lymphocyte antiprolifeartive activity.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

flavonol glycosides from euphorbia microsciadia bioss. with their immunomodulatory activities

four known flavonoids: quercetin 3-o-β-d-rutinoside (q3rut), myricetin 3-o-β-d-galactopyranoside (m3gal), quercetin 3-o-β-d-galactopyranoside (q3gal) and quercetin 3-o-β-d-glucopyranoside (q3glc), for the first time were isolated from aerial parts of euphorbia microsciadia. the chemical structure of them was elucidated on the basis of 1 and 2 d-nmr spectra and different spectroscopic techniques...

متن کامل

Flavonol glycosides from Epimedium pubescens.

Five new flavonol glycosides (1, 3, 5-7) were isolated from the aerial parts of Epimedium pubescens Maxim., along with two known compounds, sagittasine C (2) and 4',5-dihydroxyl-8-(3,3-dimethylallyl)-flavonol 3-O-[β-D-xylopyranosyl(1→3)-4-O-acetyl-α-L-rhamnopyranoside]-7-O-β-D-glucopyranoside (4). The structures were elucidated on the basis of their 1D-, 2D-NMR, MS, UV and IR spectra data.

متن کامل

Flavonol glycosides from Cadaba glandulosa.

A new flavonol triglycoside, rhamnocitrin-3-O-neohesperoside-4'-O-glucoside was isolated from the ethanol extract of Cadaba glandulosa together with two known diglycosides rhamnocitrin-3-O-neohesperoside and rhamnetin-3-neohesperoside. Characterization of the three compounds was achieved by various spectroscopic methods.

متن کامل

Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities.

Three new sesquiterpenes, (2R,3S,5R)-2,3-epoxy-6,9-humuladien-5-ol-8-one (1), (2R,3R,5R)-2,3-epoxy-6,9-humuladien-5-ol-8-one (2), and (5R)-2,6,9-humulatrien-5-ol-8-one (3), and two new flavonol glycosides, kaempferol-3-O-(2,3-di-O-acetyl-alpha-l-rhamnopyranoside) (4) and kaempferol-3-O-(2,3,4-tri-O-acetyl-alpha-l-rhamnopyranoside) (5), were isolated from the EtOAc-soluble fraction of the water ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 11  شماره 3

صفحات  925- 930

تاریخ انتشار 2012-08-15

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023